Anti-atherosclerotic effect of Farnesoid-X-Receptor in ApoE mice
نویسندگان
چکیده
Abbreviations: acetyl-CoA carboxylase (ACC); acetyl-CoA synthetase (AceCS); carnitine palmitoyltransferase I (CPT-I); chenodeoxycholic acid (CDCA); cholesterol 7 hydroxylase (CYP7A1); cholic acid (CA); farnesoid X receptor (FXR); fatty acid synthase (FAS); LDL receptor (LDL-R); INT-747, 6ethyl-CDCA; liver X receptor (LXR; long-chain acyl-CoA dehydrogenase (LCAD); malic enzyme (ME); medium-chain acylCoA dehydrogenase (MCAD); retinoid X receptor (RXR); short heterodimer partner (SHP); triglyceride (TG). Articles in PresS. Am J Physiol Heart Circ Physiol (November 21, 2008). doi:10.1152/ajpheart.01075.2008
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Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice.
The farnesoid X receptor (FXR) is a bile acid-activated transcription factor that regulates the expression of genes critical for bile acid and lipid homeostasis. This study was undertaken to investigate the pathological consequences of the loss of FXR function on the risk and severity of atherosclerosis. For this purpose, FXR-deficient (FXR-/-) mice were crossed with apolipoprotein E-deficient ...
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